金博宝app体育

What is the Rhesus Blood Group?

1

恒河猴或Rh,血型是人类已知的35个血型系统的一部分,并且是ABO系统之后的第二最重要的血型。1The latter blood group system is the one that determines if we have A, B, AB, or O type blood and this depends on which of these proteins are present on the surfaces of our red blood cells.

Rh血型系统涉及50种不同的血型蛋白质和五个最重要的是d,C,C,E,和e。当恒河猴测试是在一个单独的实施,它确定d抗原是否存在于该红血细胞或不的表面上,这是由说明该人或者是铑正或负指示。抗原红血细胞的表面上的d的存在或不存在依赖于个体的父母,因为蛋白质是继承和人的大约85%是Rh阳性。

恒河猴的历史

恒河猴血型于1937年发现并恒河猴而得名。这样做的原因是因为含有恒河猴血型的抗原血清通过免疫与猕猴的血兔产生的。2

Clinical implications

In certain situations, a Rh incompatibility between individuals may result in a medical condition known as hemolytic disease of the newborn or Rhesus disease where the red blood cells in the bloodstream of the fetus are damaged due to antibodies attacking the surfaces of the cells.3在一个pregnancy,准妈妈在她的产前检查,以确定她的生殖健康状况是什么样的测试。

母亲为Rh阴性

在这种情况下,孩子的父亲也被测试的两种情形之一发生。

  • If the father is Rh-negative, then the fetus will also be D antigen negative and there won’t be any incompatibility issues.
  • If the father is Rh positive, then there is a chance that the fetus will also be Rh positive. What this means is that when the mother and fetus’ blood come into contact with each other, the maternal blood will recognise the fetus blood as foreign (because there’s no D antigen on the surface of the red blood cells) and the maternal immune system will start to produce antibodies known as IgG anti-D antibodies which attack the D antigens and this results in damage to the red blood cells of the fetus. The baby from the woman’s first pregnancy won’t really be affected because maternal and fetal blood only comes into contact with each other during childbirth, whether it’s a normal vaginal delivery or via Caesarean section. The time of exposure is therefore limited and no damage to the baby’s red blood cells occurs. Rhesus disease will be an issue in the proceeding pregnancies though because the mother has the anti-D antibodies circulating in her bloodstream and this will come into contact with the next fetus and cause damage to its red blood cells.

The mother is Rh positive

  • Since most people are Rh positive the father won’t routinely be tested. If he is and the result is Rh positive then the fetus will also be Rhesus positive.
  • If the father is Rh-negative, there is a chance that the fetus will also be Rh negative. This scenario isn’t as problematic as the aforementioned issue because when there is contact between the mother and baby’s blood, the child’s immune system will produce the IgG anti-D antibodies. However, this won’t matter because the mother and child’s blood doesn’t come into contact again after childbirth. Where this scenario may be problematic is if the child is female, as she has the potential to become pregnant later on in life, and she has circulating anti-D antibodies that may affect her fetus if it’s Rh positive.

如今虽然,如果有一个Rh不相容问题,即母亲为Rh阴性,期间和怀孕,以防止她的免疫系统从产生抗体后IgG抗d疫苗给予母亲。请务必遵循正确的测试。在Xpertdoxyou can find best doctors or hospitals for treating any rare disease.

参考

1.迪恩L.血型与红细胞抗原[互联网]。贝塞斯达(MD):美国国家生物技术信息中心(美国);金博宝体育app2005年第7章,Rh血型。可从以下https://www.ncbi.nlm.nih.gov/books/NBK2269/

2.兰茨泰纳,K .;韦纳,A.(1940)。“一个Agglutinable因子在血液免疫血清为Rh血型认可”。Exp Biol Med. 43 (1): 223.DOI:10.3181/00379727-43-11151.

3.迪恩L.血型与红细胞抗原[互联网]。贝塞斯达(MD):美国国家生物技术信息中心(美国);金博宝体育app2005. Chapter 4, Hemolytic disease of the newborn. Available from: https://www.ncbi.nlm.nih.gov/books/NBK2266/

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